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Who was studied 983 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.13 higher; p = 1 × 10−14.
How common The A allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of APOC1.
What each result means
A/ATwo copies of the version the research linked to Cerebral amyloid deposition (PET imaging). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cerebral amyloid deposition (PET imaging). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cerebral amyloid deposition (PET imaging). This is the starting point the study compared everyone against.
Molecular psychiatry · 2021 · PMID 30361487 · open access
Questions about rs12721046
What is rs12721046?
rs12721046 is a single position in the genome, in or near the APOC1 gene. Published research associates it with cerebral amyloid deposition (pet imaging). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12721046 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does having rs12721046 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12721046 come from?
GWAS Catalog, Mol Psychiatry 2018, PMID:30361487. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 33324122217Reads by AI crawlersClaude0ChatGPT3Google · Gemini0Perplexity2Meta AI4Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others17Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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