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Apolipoprotein B levels

APOB · rs12720796

What the study found

Who was studied 439,214 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.051 lower (95% confidence interval 0.036-0.066); p = 8 × 10−12.

How common The A allele had a frequency of about 98% in the people studied.

Where it sits Chromosome 2, band 2p24.1 — in an intron of APOB.

What each result means

A/A Two copies of the version the research linked to Apolipoprotein B levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Apolipoprotein B levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to Apolipoprotein B levels. This is the starting point the study compared everyone against.
Source

Questions about rs12720796

What is rs12720796?

rs12720796 is a single position in the genome, in or near the APOB gene. Published research associates it with apolipoprotein b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12720796 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12720796 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Apolipoprotein B levels (rs12720796). MyGeneLog™. https://www.mygenelog.com/variants/rs12720796

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