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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 77,183 European ancestry individuals (MTAG effective sample size boosted by aortic valve function and stenosis samples).
The effect
Each copy of the A allele shifted the measure 0.0353 higher (95% confidence interval 0.025-0.045); p = 3 × 10−12.
How common The A allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 10, band 10q22.1 — between genes, 15.2 kb from CHST3.
What each result means
A/ATwo copies of the version the research linked to Aortic valve area (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Aortic valve area (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Aortic valve area (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs1271934
What is rs1271934?
rs1271934 is a single position in the genome, in or near the near CHST3 gene. Published research associates it with aortic valve area (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1271934 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1271934 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Aortic valve area (MTAG) (rs1271934). MyGeneLog™. https://www.mygenelog.com/variants/rs1271934