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Body size at age 10

LRRTM4 · rs12713889

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 453,169 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0117 higher (95% confidence interval 0.0088-0.0146); p = 4 × 10⁻¹⁵.

How common The T allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 2, band 2p12 — in an intron of LRRTM4.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Body size at age 10 — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body size at age 10.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body size at age 10 compared to the general population.

Source

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G

BMJ (Clinical research ed.) · 2020 · PMID 32376654 · open access

Questions about rs12713889

What is rs12713889?

rs12713889 is a single position in the genome, in or near the LRRTM4 gene. Published research associates it with body size at age 10. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12713889 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12713889 come from?

GWAS Catalog, BMJ (Clinical research ed.) 2020, PMID:32376654. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body size at age 10 (rs12713889). MyGeneLog™. https://www.mygenelog.com/variants/rs12713889

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