Standard
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)
BCL2L11 · rs12711846
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy).
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) compared to the general population.
Source
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci
Law PJ,
Sud A,
Mitchell JS,
Henrion M,
Orlando G,
Lenive O,
Broderick P,
Speedy HE,
Johnson DC,
Kaiser M,
Weinhold N,
Cooke R
and 29 more — show all
Sunter NJ,
Jackson GH,
Summerfield G,
Harris RJ,
Pettitt AR,
Allsup DJ,
Carmichael J,
Bailey JR,
Pratt G,
Rahman T,
Pepper C,
Fegan C,
von Strandmann EP,
Engert A,
Försti A,
Chen B,
Filho MI,
Thomsen H,
Hoffmann P,
Noethen MM,
Eisele L,
Jöckel KH,
Allan JM,
Swerdlow AJ,
Goldschmidt H,
Catovsky D,
Morgan GJ,
Hemminki K,
Houlston RS
Scientific reports · 2017 · PMID 28112199 · open access
Questions about rs12711846
What is rs12711846?
rs12711846 is a single position in the genome, in or near the BCL2L11 gene. Published research associates it with b-cell malignancies (chronic lymphocytic leukemia, hodgkin lymphoma or multiple myeloma) (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12711846 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12711846 come from?
GWAS Catalog, Sci Rep 2017, PMID:28112199. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants