Sensitive

Prostate cancer

TBX5 · rs1270884

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate cancer compared to the general population. (GWAS Catalog, Nat Genet 2013, PMID:23535732)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate cancer. (GWAS Catalog, Nat Genet 2013, PMID:23535732)

G/G Published research associates this genotype with typical/baseline likelihood of Prostate cancer — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2013, PMID:23535732)

Source

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE

and 132 more — show all

Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, Kote-Jarai Z, Easton DF

COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative · Australian Prostate Cancer Bioresource · UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology · UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators · PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium

Nature genetics · 2013 · PMID 23535732

Questions about rs1270884

What is rs1270884?

rs1270884 is a single position in the genome, in or near the TBX5 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1270884 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs1270884 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1270884 come from?

GWAS Catalog, Nat Genet 2013, PMID:23535732. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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