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Who was studied 2,000 European ancestry cases, 3,000 European ancestry controls; replicated in 2,997 European ancestry trios, 4,000 European ancestry cases, 5,000 European ancestry controls.
The effect
Each copy of the A allele carried 1.23 times the odds of Type 1 diabetes (95% confidence interval 1.16-1.30); p = 3 × 10−18.
How common The A allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 16, band 16p13.13 — in an intron of CLEC16A.
What each result means
A/ATwo copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs12708716
What is rs12708716?
rs12708716 is a single position in the genome, in or near the KIAA0350 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12708716 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs12708716?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), gut and food intolerance (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs12708716 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12708716 come from?
GWAS Catalog, Nat Genet 2007, PMID:17554260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs12708716). MyGeneLog™. https://www.mygenelog.com/variants/rs12708716