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Its strongest genetic-study result is p = 10−22, with 26 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the A allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 2 × 10−22.
Where it sits Chromosome 7, band 7p22.3 — in an intron of GPR146.
What each result means
A/ATwo copies of the version the research linked to Cholesteryl Esters to Total Lipids in Very Large HDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cholesteryl Esters to Total Lipids in Very Large HDL percentage. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cholesteryl Esters to Total Lipids in Very Large HDL percentage. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs12701713
What is rs12701713?
rs12701713 is a single position in the genome, in or near the CHLSN gene. Published research associates it with cholesteryl esters to total lipids in very large hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12701713 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs12701713 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12701713 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cholesteryl Esters to Total Lipids in Very Large HDL percentage (rs12701713). MyGeneLog™. https://www.mygenelog.com/variants/rs12701713