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Asthma

ITGB8 · rs12700186

Where this position leads

Condition: Asthma

rs12700186 Condition: Asthma Asthma Condition rs12700186 rs12700186 ITGB8

What the study found

Who was studied 16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls.

The effect Each copy of the T allele carried 1.04 times the odds of Asthma (95% confidence interval 1.02-1.05); p = 3 × 10−8.

How common The T allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 7, band 7p21.1 — in an intron of ITGB8.

What each result means

C/C No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Olafsdottir TA, Theodors F, Bjarnadottir K, Bjornsdottir US, Agustsdottir AB, Stefansson OA, Ivarsdottir EV, Sigurdsson JK, Benonisdottir S, Eyjolfsson GI, Gislason D, Gislason T
and 23 more — show all
Guðmundsdóttir S, Gylfason A, Halldorsson BV, Halldorsson GH, Juliusdottir T, Kristinsdottir AM, Ludviksdottir D, Ludviksson BR, Masson G, Norland K, Onundarson PT, Olafsson I, Sigurdardottir O, Stefansdottir L, Sveinbjornsson G, Tragante V, Gudbjartsson DF, Thorleifsson G, Sulem P, Thorsteinsdottir U, Norddahl GL, Jonsdottir I, Stefansson K
Nature communications · 2020 · PMID 31959851 · open access

Questions about rs12700186

What is rs12700186?

rs12700186 is a single position in the genome, in or near the ITGB8 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12700186 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs12700186 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12700186 come from?

GWAS Catalog, Nature communications 2020, PMID:31959851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs12700186). MyGeneLog™. https://www.mygenelog.com/variants/rs12700186

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