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Who was studied 489,579 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.014 higher (95% confidence interval 0.0098-0.0183); p = 1 × 10−10.
Where it sits Chromosome 7, band 7p21.3 — between genes, 0.3 kb from TMEM106B.
What each result means
A/ATwo copies of the version the research linked to Generalized anxiety disorder (phenotype risk score). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Generalized anxiety disorder (phenotype risk score). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Generalized anxiety disorder (phenotype risk score). This is the starting point the study compared everyone against.
Molecular psychiatry · 2022 · PMID 35181757 · open access
Questions about rs12699336
What is rs12699336?
rs12699336 is a single position in the genome, in or near the near TMEM106B gene. Published research associates it with generalized anxiety disorder (phenotype risk score). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12699336 linked to?
On MyGeneLog this position is linked to Anxiety Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs12699336 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12699336 come from?
GWAS Catalog, Molecular psychiatry 2022, PMID:35181757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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