ADAM17 · rs12692386
Where this position leads
Condition: Birth Weight
What the study found
Who was studied 241,168 British ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.0141 kg lower (95% confidence interval 0.011-0.017); p = 2 × 10−18.
What ClinVar records
Classification
Benign for Mycobacterium tuberculosis, susceptibility to; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2018-11-10.
ClinVar record 1227372 NM_003183.6(ADAM17):c.-172T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs12692386 is a single position in the genome, in or near the ADAM17 gene. Published research associates it with birth weight (winsorised). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Birth Weight. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Diabetologia 2025, PMID:40210729. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Birth weight (winsorised) (rs12692386). MyGeneLog™. https://www.mygenelog.com/variants/rs12692386