Sensitive

NSAID-induced peptic ulcer disease

EYA1 · rs12678747

Where this position leads

Condition: Peptic Ulcer Disease

rs12678747 Condition: Peptic Ulcer Disease Peptic Ulcer Disease Condition rs12678747 rs12678747 EYA1

What the study found

Who was studied 235 European ancestry cases, 441 European ancestry controls; replicated in 206 European ancestry cases, 309 European ancestry controls.

The effect Each copy of the T allele carried 2.03 times the odds of NSAID-induced peptic ulcer disease (95% confidence interval 1.65-2.5); p = 3 × 10−11.

Where it sits Chromosome 8, band 8q13.3 — in an intron of EYA1.

What each result means

A/A No copy of the version the research linked to NSAID-induced peptic ulcer disease. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to NSAID-induced peptic ulcer disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to NSAID-induced peptic ulcer disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs12678747

What is rs12678747?

rs12678747 is a single position in the genome, in or near the EYA1 gene. Published research associates it with nsaid-induced peptic ulcer disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12678747 linked to?

On MyGeneLog this position is linked to Peptic Ulcer Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs12678747 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12678747 come from?

GWAS Catalog, EBioMedicine 2021, PMID:34864618. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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NSAID-induced peptic ulcer disease (rs12678747). MyGeneLog™. https://www.mygenelog.com/variants/rs12678747

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