Standard

PR interval

ZFPM2 · rs12678719

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

What the study found

Who was studied 92,340 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.8 ms higher (95% confidence interval 0.55-1.05); p = 4 × 10⁻¹⁰.

How common The G allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 8, band 8q23.1 — in an intron of ZFPM2.

What each result means

C/C No copy of the version the research linked to PR interval. This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to PR interval. That is a smaller link than two copies.

G/G Two copies of the version the research linked to PR interval. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP

and 114 more — show all

Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Waldenberger M, Jan Westra H, Wild PS, Zeller T, Alonso A, Avery CL, Bandinelli S, Benjamin EJ, Cucca F, Dörr M, Ferrucci L, Gasparini P, Gudnason V, Hayward C, Heckbert SR, Hicks AA, Jukema JW, Kääb S, Lehtimäki T, Liu Y, Munroe PB, Parsa A, Polasek O, Psaty BM, Roden DM, Schnabel RB, Sinagra G, Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N

Nature communications · 2018 · PMID 30046033 · open access

Questions about rs12678719

What is rs12678719?

rs12678719 is a single position in the genome, in or near the ZFPM2 gene. Published research associates it with pr interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12678719 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs12678719 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12678719 come from?

GWAS Catalog, Nature communications 2018, PMID:30046033. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

PR interval (rs12678719). MyGeneLog™. https://www.mygenelog.com/variants/rs12678719

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