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Who was studied 737 Ashkenazi Jewish cases, 2,257 Ashkenazi Jewish controls; replicated in 971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Crohn's disease (95% confidence interval 1.04-1.28); p = 2 × 10−8.
How common The T allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 8, band 8q21.11 — inside SBSPON.
What each result means
G/GNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
PLoS genetics · 2012 · PMID 22412388 · open access
Questions about rs12677663
What is rs12677663?
rs12677663 is a single position in the genome, in or near the C8orf84 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12677663 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12677663 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12677663 come from?
GWAS Catalog, PLoS Genet 2012, PMID:22412388. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4432217223220Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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