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Who was studied 286,581 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.742 lower (95% confidence interval 0.57-0.92); p = 8 × 10−11.
Where it sits Chromosome 6, band 6q25.1 — in an intron of PLEKHG1.
What each result means
G/GNo copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Scientific reports · 2024 · PMID 39548300 · open access
Questions about rs12664595
What is rs12664595?
rs12664595 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12664595 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs12664595 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12664595 come from?
GWAS Catalog, Scientific reports 2024, PMID:39548300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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