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Who was studied 88,192 cases, 162,544 controls; replicated in 34,541 cases, 261,984 controls.
The effect
Each copy of the T allele shifted the measure 0.0591 lower (95% confidence interval 0.04-0.078); p = 1 × 10−9.
How common The T allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 6, band 6q25.1 — in an intron of PLEKHG1.
What each result means
C/CNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Circulation research · 2018 · PMID 29212778 · open access
Questions about rs12663498
What is rs12663498?
rs12663498 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12663498 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12663498 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12663498 come from?
GWAS Catalog, Circ Res 2017, PMID:29212778. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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