3 4932348223220Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity4Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied Up to 12,924 European ancestry cases, up to 21,442 European ancestry controls; replicated in Up to 25,683 European ancestry cases, up to 17,015 European ancestry controls.
The effect
Each copy of the C allele carried 1.09 times the odds of Crohn's disease (95% confidence interval 1.06-1.131); p = 4 × 10−12.
How common The C allele had a frequency of about 53% in the people studied.
Where it sits Chromosome 6, band 6p22.3 — between genes, 55.1 kb from LINC00581.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs12663356 is a single position in the genome, in or near the near SOX4 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12663356 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12663356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12663356 come from?
GWAS Catalog, Nature 2012, PMID:23128233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4932348223220Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity4Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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