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Who was studied 78,300 British ancestry cases, 288,888 British ancestry controls.
The effect
Each copy of the A allele carried 0.92 times the odds of Metabolic syndrome (95% confidence interval 0.9-0.94); p = 1 × 10−11.
How common The A allele had a frequency of about 94% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 1.2 kb from RNU6-283P.
What each result means
A/ATwo copies of the version the research linked to Metabolic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Metabolic syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Metabolic syndrome. This is the starting point the study compared everyone against.
rs12660817 is a single position in the genome, in or near the near RNU6-283P gene. Published research associates it with metabolic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12660817 linked to?
On MyGeneLog this position is linked to Metabolic Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs12660817 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12660817 come from?
GWAS Catalog, Functional & integrative genomics 2026, PMID:42472903. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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