Sensitive

Systemic lupus erythematosus

near LY6G5C · rs1266075

Where this position leads

Condition: Systemic Lupus Erythematosus

rs1266075 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs1266075 rs1266075 near LY6G5C

What the study found

Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.2 lower (95% confidence interval 0.16-0.24); p = 2 × 10−26.

What each result means

A/A Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
G/G No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
Source

Questions about rs1266075

What is rs1266075?

rs1266075 is a single position in the genome, in or near the near LY6G5C gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1266075 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs1266075 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1266075 come from?

GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs1266075). MyGeneLog™. https://www.mygenelog.com/variants/rs1266075

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