Standard
Mammographic density (dense area)
AREG · rs12642133
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mammographic density (dense area) compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mammographic density (dense area).
G/G
Published research associates this genotype with typical/baseline likelihood of Mammographic density (dense area) — no copies of the reported risk allele.
Source
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
Lindström S,
Thompson DJ,
Paterson AD,
Li J,
Gierach GL,
Scott C,
Stone J,
Douglas JA,
dos-Santos-Silva I,
Fernandez-Navarro P,
Verghase J,
Smith P
and 33 more — show all
Brown J,
Luben R,
Wareham NJ,
Loos RJ,
Heit JA,
Pankratz VS,
Norman A,
Goode EL,
Cunningham JM,
deAndrade M,
Vierkant RA,
Czene K,
Fasching PA,
Baglietto L,
Southey MC,
Giles GG,
Shah KP,
Chan HP,
Helvie MA,
Beck AH,
Knoblauch NW,
Hazra A,
Hunter DJ,
Kraft P,
Pollan M,
Figueroa JD,
Couch FJ,
Hopper JL,
Hall P,
Easton DF,
Boyd NF,
Vachon CM,
Tamimi RM
Nature communications · 2014 · PMID 25342443 · open access
Questions about rs12642133
What is rs12642133?
rs12642133 is a single position in the genome, in or near the AREG gene. Published research associates it with mammographic density (dense area). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12642133 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12642133 come from?
GWAS Catalog, Nat Commun 2014, PMID:25342443. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants