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Who was studied 140,886 European ancestry individuals; replicated in 190,318 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.24 higher (95% confidence interval 0.18-0.3); p = 6 × 10−12.
How common The T allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 22, band 22q11.21 — in an intron of ARVCF.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-05-10.
ClinVar record 1243026NM_001670.3(ARVCF):c.897-215G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Pulse pressure. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Pulse pressure. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pulse pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2017 · PMID 28135244 · open access
Questions about rs12628032
What is rs12628032?
rs12628032 is a single position in the genome, in or near the ARVCF gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12628032 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs12628032 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12628032 come from?
GWAS Catalog, Nat Genet 2017, PMID:28135244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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