PT international normalized ratio (INR, minimum, inv-norm transformed)
TTC7A · rs12621059
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Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 49,241 African American or Afro-Caribbean individuals, 23,426 Hispanic or Latin American individuals, 1,793 East Asian ancestry individuals, 165,202 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0284 higher (95% confidence interval 0.02-0.037); p = 4 × 10−11.
How common The T allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 2, band 2p21 — in an intron of TTC7A.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of PT international normalized ratio (INR, minimum, inv-norm transformed) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with PT international normalized ratio (INR, minimum, inv-norm transformed).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of PT international normalized ratio (INR, minimum, inv-norm transformed) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs12621059
What is rs12621059?
rs12621059 is a single position in the genome, in or near the TTC7A gene. Published research associates it with pt international normalized ratio (inr, minimum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12621059 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12621059 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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PT international normalized ratio (INR, minimum, inv-norm transformed) (rs12621059). MyGeneLog™. https://www.mygenelog.com/variants/rs12621059