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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 35,657 White British ancestry individuals.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−17.
How common The T allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.
What each result means
A/ANo copy of the version the research linked to Cortical surface area. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Cortical surface area. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1261134 is a single position in the genome, in or near the TCF4 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1261134 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1261134 come from?
GWAS Catalog, NeuroImage 2021, PMID:34560273. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cortical surface area (rs1261134). MyGeneLog™. https://www.mygenelog.com/variants/rs1261134