1 4342225123220Reads by AI crawlersClaude4ChatGPT2Google · Gemini2Perplexity2Meta AI5Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 11,185 European ancestry cases, 10,768 European ancestry controls; replicated in 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals.
The effect
Each copy of the T allele carried 1.60 times the odds of Schizophrenia; p = 3 × 10−10.
How common The T allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.
What each result means
C/CNo copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1261117 is a single position in the genome, in or near the TCF4 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1261117 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs1261117 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1261117 come from?
GWAS Catalog, JAMA Psychiatry 2013, PMID:23894747. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4342225123220Reads by AI crawlersClaude4ChatGPT2Google · Gemini2Perplexity2Meta AI5Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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