Sensitive

Multiple sclerosis

SMARCA4 · rs12609500

Where this position leads

Condition: Multiple Sclerosis

rs12609500 Condition: Multiple Sclerosis Multiple Sclerosis Condition rs12609500 rs12609500 SMARCA4

What the study found

Who was studied 14,802 European and unknown ancestry cases, 26,703 European and unknown ancestry controls; replicated in 32,627 European and unknown ancestry cases, 41,672 European and unknown ancestry controls.

The effect Each copy of the C allele carried 1.06 times the odds of Multiple sclerosis; p = 5 × 10−9.

Where it sits Chromosome 19, band 19p13.2 — inside SMARCA4.

What each result means

C/C Two copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
T/T No copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
Source

Questions about rs12609500

What is rs12609500?

rs12609500 is a single position in the genome, in or near the SMARCA4 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12609500 linked to?

On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs12609500 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12609500 come from?

GWAS Catalog, Science 2019, PMID:31604244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Multiple sclerosis (rs12609500). MyGeneLog™. https://www.mygenelog.com/variants/rs12609500

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