Standard

High-sensitivity cardiac troponin I concentration

LMAN1 · rs12604424

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 48,115 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.06 higher (95% confidence interval 0.04-0.08); p = 1 × 10⁻¹¹.

How common The C allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 18, band 18q21.32 — in an intron of LMAN1.

What each result means

C/C Two copies of the version the research linked to High-sensitivity cardiac troponin I concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to High-sensitivity cardiac troponin I concentration. That is a smaller link than two copies.

T/T No copy of the version the research linked to High-sensitivity cardiac troponin I concentration. This is the starting point the study compared everyone against.

Source

Genome-wide association study of cardiac troponin I in the general population

Moksnes MR, Røsjø H, Richmond A, Lyngbakken MN, Graham SE, Hansen AF, Wolford BN, Gagliano Taliun SA, LeFaive J, Rasheed H, Thomas LF, Zhou W

and 18 more — show all

Aung N, Surakka I, Douville NJ, Campbell A, Porteous DJ, Petersen SE, Munroe PB, Welsh P, Sattar N, Smith GD, Fritsche LG, Nielsen JB, Åsvold BO, Hveem K, Hayward C, Willer CJ, Brumpton BM, Omland T

Human molecular genetics · 2021 · PMID 33961016 · open access

Questions about rs12604424

What is rs12604424?

rs12604424 is a single position in the genome, in or near the LMAN1 gene. Published research associates it with high-sensitivity cardiac troponin i concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12604424 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12604424 come from?

GWAS Catalog, Human molecular genetics 2021, PMID:33961016. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High-sensitivity cardiac troponin I concentration (rs12604424). MyGeneLog™. https://www.mygenelog.com/variants/rs12604424

← See all variants