Sensitive

Cervical cancer

ORMDL3 · rs12603332

Where this position leads

Condition: Cervical Cancer

rs12603332 Condition: Cervical Cancer Cervical Cancer Condition rs12603332 rs12603332 ORMDL3

What the study found

Who was studied 8,624 European ancestry cases, 400,573 European ancestry controls.

The effect Each copy of the C allele carried 0.90 times the odds of Cervical cancer (95% confidence interval 0.88-0.93); p = 2 × 10−10.

How common The C allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 17, band 17q21.1 — in the 5′ untranslated region of ORMDL3.

What each result means

C/C Two copies of the version the research linked to Cervical cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Cervical cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Cervical cancer. This is the starting point the study compared everyone against.
Source

Questions about rs12603332

What is rs12603332?

rs12603332 is a single position in the genome, in or near the ORMDL3 gene. Published research associates it with cervical cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12603332 linked to?

On MyGeneLog this position is linked to Cervical Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12603332 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12603332 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36929174. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cervical cancer (rs12603332). MyGeneLog™. https://www.mygenelog.com/variants/rs12603332

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