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Alcohol consumption (heavy vs. light/non-drinkers)

CDH13 · rs12599112

Where this position leads

What the study found

Who was studied up to 74,711 European ancestry heavy and light/non-drinker individuals; replicated in up to 31,021 European ancestry heavy and light/non-drinker individuals.

The effect Each copy of the A allele shifted the measure 0.0733 lower (95% confidence interval 0.048-0.099); p = 5 × 10⁻⁸.

Where it sits Chromosome 16, band 16q23.3 — in an intron of CDH13.

What each result means

A/A Two copies of the version the research linked to Alcohol consumption (heavy vs. light/non-drinkers). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/C One copy of the version the research linked to Alcohol consumption (heavy vs. light/non-drinkers). That is a smaller link than two copies.

C/C No copy of the version the research linked to Alcohol consumption (heavy vs. light/non-drinkers). This is the starting point the study compared everyone against.

Source

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S

and 115 more — show all

Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Harst P, van Duijn CM, Marques-Vidal P, Vollenweider P, Wareham NJ, Whitfield JB, Wilson J, Wolffenbuttel B, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P

Proceedings of the National Academy of Sciences of the United States of America · 2016 · PMID 27911795

Questions about rs12599112

What is rs12599112?

rs12599112 is a single position in the genome, in or near the CDH13 gene. Published research associates it with alcohol consumption (heavy vs. light/non-drinkers). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12599112 linked to?

On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.

Does having rs12599112 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12599112 come from?

GWAS Catalog, Proc Natl Acad Sci U S A 2016, PMID:27911795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alcohol consumption (heavy vs. light/non-drinkers) (rs12599112). MyGeneLog™. https://www.mygenelog.com/variants/rs12599112

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