0 71123Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.025 higher (95% confidence interval 0.017-0.033); p = 8 × 10−10.
Where it sits Chromosome 12, band 12p11.21 — between genes, 17.7 kb from H3-5.
What each result means
C/CTwo copies of the version the research linked to Insulin-like growth factor 1 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Insulin-like growth factor 1 levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Insulin-like growth factor 1 levels. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs1259633
What is rs1259633?
rs1259633 is a single position in the genome, in or near the near H3-5 gene. Published research associates it with insulin-like growth factor 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1259633 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs1259633 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1259633 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 71123Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.