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Who was studied 1,122,049 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0289 lower (95% confidence interval 0.024-0.033); p = 8 × 10−35.
Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.
What each result means
A/ANo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 36581621 · open access
Questions about rs12596054
What is rs12596054?
rs12596054 is a single position in the genome, in or near the FTO gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12596054 linked to?
On MyGeneLog this position is linked to Obesity and Body Weight, Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.
Does having rs12596054 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12596054 come from?
GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 142111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs12596054). MyGeneLog™. https://www.mygenelog.com/variants/rs12596054