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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 562,259 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0274 SD unit higher (95% confidence interval 0.019-0.035); p = 4 × 10−11.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 13, band 13q34 — in an intron of IRS2.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hematocrit compared to the general population.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hematocrit.
C/CPublished research associates this genotype with typical/baseline likelihood of Hematocrit — no copies of the reported risk allele.
rs12584136 is a single position in the genome, in or near the IRS2 gene. Published research associates it with hematocrit. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12584136 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12584136 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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