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Standard

Height

ZMIZ1 · rs12572275

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−13, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.012 lower (95% confidence interval 0.0089-0.0151); p = 4 × 10−14.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 10, band 10q22.3 — in an intron of ZMIZ1.

What each result means

C/C No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs12572275). MyGeneLog™. https://www.mygenelog.com/variants/rs12572275

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