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COVID-19

FLNB · rs1256764500

What the study found

Who was studied 1,146 African ancestry cases, 21,959 African ancestry controls, 88 Admixed American cases, 1,307 Admixed American controls, 80 East Asian ancestry cases, 2,085 East Asian ancestry controls, 18,920 European ancestry cases, 530,629 European ancestry controls, 718 South Asian ancestry cases, 9,225 South Asian ancestry controls.

The effect Each copy of the G allele carried 26.60 times the odds of COVID-19 (95% confidence interval 8.25-85.77); p = 4 × 10−8.

How common The G allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 3, band 3p14.3 — a missense change in FLNB.

What each result means

A/A No copy of the version the research linked to COVID-19. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to COVID-19. That is a smaller link than two copies.
G/G Two copies of the version the research linked to COVID-19. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1256764500

What is rs1256764500?

rs1256764500 is a single position in the genome, in or near the FLNB gene. Published research associates it with covid-19. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1256764500 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1256764500 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34115965. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (rs1256764500). MyGeneLog™. https://www.mygenelog.com/variants/rs1256764500

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