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Sleep duration (short sleep)

DPYD · rs12567114

Where this position leads

Drug: Fluoropyrimidines

rs12567114 Drug: Fluoropyrimidines Fluoropyrimidines Drug rs12567114 rs12567114 DPYD

What the study found

Who was studied 106,192 European ancestry cases, 305,742 European ancestry controls; replicated in 47,180 adults, 10,554 children or adolescents.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10−9.

Where it sits Chromosome 1, band 1p21.3 — between genes, 7.7 kb from MIR137HG.

What each result means

A/A No copy of the version the research linked to Sleep duration (short sleep). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Sleep duration (short sleep). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Sleep duration (short sleep). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs12567114

What is rs12567114?

rs12567114 is a single position in the genome, in or near the DPYD gene. Published research associates it with sleep duration (short sleep). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs12567114 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs12567114 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12567114 come from?

GWAS Catalog, Nat Commun 2019, PMID:30846698. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sleep duration (short sleep) (rs12567114). MyGeneLog™. https://www.mygenelog.com/variants/rs12567114

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