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Cardiac Troponin-T levels

TNNT2 · rs12564445

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 9,491 European ancestry individuals, up to 2,053 African American individuals.

The effect Each copy of the A allele carried 2.33 times the odds of Cardiac Troponin-T levels (95% confidence interval 1.72-3.16); p = 5 × 10⁻⁸.

Where it sits Chromosome 1, band 1q32.1 — in an intron of TNNT2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cardiac Troponin-T levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cardiac Troponin-T levels.

G/G Published research associates this genotype with typical/baseline likelihood of Cardiac Troponin-T levels — no copies of the reported risk allele.

Source

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies

Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen RC, Tang W, Mosley TH, Rotter JI, deFilippi CR, O'Donnell CJ, Kathiresan S, Rice K

and 4 more — show all

Heckbert SR, Ballantyne CM, Psaty BM, Boerwinkle E

CARDIoGRAM Consortium

Circulation. Cardiovascular genetics · 2013 · PMID 23247143

Questions about rs12564445

What is rs12564445?

rs12564445 is a single position in the genome, in or near the TNNT2 gene. Published research associates it with cardiac troponin-t levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12564445 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12564445 come from?

GWAS Catalog, Circ Cardiovasc Genet 2012, PMID:23247143. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cardiac Troponin-T levels (rs12564445). MyGeneLog™. https://www.mygenelog.com/variants/rs12564445

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