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Medication use (agents acting on the renin-angiotensin system)

near FXN · rs12555832

What the study found

Who was studied 62,752 European ancestry cases, 174,778 European ancestry controls, 45,820 East Asian ancestry cases, 132,906 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0657 higher (95% confidence interval 0.046-0.086); p = 2 × 10−10.

Where it sits Chromosome 9, band 9q21.11 — between genes, 9.5 kb from FXN.

What each result means

A/A Two copies of the version the research linked to Medication use (agents acting on the renin-angiotensin system). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Medication use (agents acting on the renin-angiotensin system). That is a smaller link than two copies.
G/G No copy of the version the research linked to Medication use (agents acting on the renin-angiotensin system). This is the starting point the study compared everyone against.
Source

Questions about rs12555832

What is rs12555832?

rs12555832 is a single position in the genome, in or near the near FXN gene. Published research associates it with medication use (agents acting on the renin-angiotensin system). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12555832 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12555832 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Medication use (agents acting on the renin-angiotensin system) (rs12555832). MyGeneLog™. https://www.mygenelog.com/variants/rs12555832

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