Sensitive

Uterine leiomyoma or breast cancer (pleiotropy)

ASTN2 · rs12555322

Where this position leads

Condition: Breast Cancer

rs12555322 Condition: Breast Cancer Breast Cancer Condition rs12555322 rs12555322 ASTN2

What the study found

Who was studied 35,474 European ancestry UL cases, 133,384 European ancestry BC cases, 381,294 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 3 × 10−11.

Where it sits Chromosome 9, band 9q33.1 — in an intron of ASTN2.

What each result means

A/A Two copies of the version the research linked to Uterine leiomyoma or breast cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine leiomyoma or breast cancer (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine leiomyoma or breast cancer (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs12555322

What is rs12555322?

rs12555322 is a single position in the genome, in or near the ASTN2 gene. Published research associates it with uterine leiomyoma or breast cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12555322 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12555322 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12555322 come from?

GWAS Catalog, American journal of human genetics 2022, PMID:35803233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine leiomyoma or breast cancer (pleiotropy) (rs12555322). MyGeneLog™. https://www.mygenelog.com/variants/rs12555322

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