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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0153 higher (95% confidence interval 0.011-0.02); p = 5 × 10−12.
How common The T allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 9, band 9q34.3 — between genes, 38.2 kb from FCN1.
What each result means
C/CNo copy of the version the research linked to Neutrophill percentage (UKB data field 30200). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Neutrophill percentage (UKB data field 30200). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Neutrophill percentage (UKB data field 30200). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs12554353
What is rs12554353?
rs12554353 is a single position in the genome, in or near the near FCN1 gene. Published research associates it with neutrophill percentage (ukb data field 30200). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12554353 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12554353 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12554353 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Neutrophill percentage (UKB data field 30200) (rs12554353). MyGeneLog™. https://www.mygenelog.com/variants/rs12554353