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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 201,533 European ancestry cases, 901,637 European ancestry controls, 5,506 East Asian ancestry cases, 126,769 East Asian ancestry controls, 4,149 African or African American cases, 21,448 African or African American controls, 1,087 South Asian ancestry cases, 18,871 South Asian ancestry controls, 842 Hispanic cases, 3,489 Hispanic controls, 722 Admixed ancestry cases, 8,268 Admixed ancestry controls.
The effect
Each copy of the A allele carried 1.03 times the odds of Osteoarthritis of the hip or knee (95% confidence interval 1.0175320758351-1.03564025362719); p = 6 × 10−9.
How common The A allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 8, band 8p23.1 — in an intron of XKR6.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis of the hip or knee. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Osteoarthritis of the hip or knee. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Osteoarthritis of the hip or knee. This is the starting point the study compared everyone against.
rs12548184 is a single position in the genome, in or near the XKR6 gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12548184 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12548184 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12548184 come from?
GWAS Catalog, Nature 2025, PMID:40205036. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Osteoarthritis of the hip or knee (rs12548184). MyGeneLog™. https://www.mygenelog.com/variants/rs12548184