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Who was studied 56,184 European ancestry cases, 90,919 European ancestry controls.
The effect
Each copy of the A allele carried 1.07 times the odds of Alzheimer's disease (95% confidence interval 1.05-1.09); p = 3 × 10−9.
How common The A allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 8, band 8q24.13 — in an intron of TRIB1AL.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs12544593
What is rs12544593?
rs12544593 is a single position in the genome, in or near the near TRIB1 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12544593 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12544593 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12544593 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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