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Who was studied 2,165 Saudi Arab ancestry cases, 2,266 Saudi Arab ancestry controls; replicated in 503 Saudi Arab ancestry cases, 734 Saudi Arab ancestry controls.
The effect
Each copy of the T allele carried 1.25 times the odds of Coronary artery disease; p = 5 × 10−13.
How common The T allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 8, band 8q21.11 — in a non-coding transcript of TRPA2P.
What each result means
C/CNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs12541758 is a single position in the genome, in or near the TRPA1 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12541758 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12541758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12541758 come from?
GWAS Catalog, Atherosclerosis 2016, PMID:26708285. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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