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Who was studied 48,843 European ancestry cases, 1,190,837 European ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 5 × 10−12.
How common The A allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 7, band 7p21.2 — between genes, 4.7 kb from CRPPA.
What each result means
A/ATwo copies of the version the research linked to Carpal tunnel syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Carpal tunnel syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Carpal tunnel syndrome. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35332129 · open access
Questions about rs12539945
What is rs12539945?
rs12539945 is a single position in the genome, in or near the near CRPPA gene. Published research associates it with carpal tunnel syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12539945 linked to?
On MyGeneLog this position is linked to Carpal Tunnel Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs12539945 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12539945 come from?
GWAS Catalog, Nature communications 2022, PMID:35332129. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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