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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 68,987 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,391,458 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the A allele shifted the measure 0.0413 higher (95% confidence interval 0.027-0.056); p = 1 × 10−8.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 7, band 7p22.3 — in an intron of MAD1L1.
What each result means
A/ATwo copies of the version the research linked to Benign nodular goiter. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Benign nodular goiter. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Benign nodular goiter. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs12536062
What is rs12536062?
rs12536062 is a single position in the genome, in or near the MAD1L1 gene. Published research associates it with benign nodular goiter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12536062 linked to?
On MyGeneLog this position is linked to Benign Nodular Goiter. The research behind each link, and its sources, are set out on that condition page.
Does having rs12536062 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12536062 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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