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Insomnia

PRKRIP1 · rs12534945

Where this position leads

What the study found

Who was studied 651,923 European ancestry males, 679,087 European ancestry females.

The effect Each copy of the C allele carried 1.06 times the odds of Insomnia (95% confidence interval 1.04-1.07); p = 3 × 10⁻¹⁰.

How common The C allele had a frequency of about 75% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — in an intron of PRKRIP1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Insomnia compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Insomnia.

T/T Published research associates this genotype with typical/baseline likelihood of Insomnia — no copies of the reported risk allele.

Source

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H

and 12 more — show all

White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D

23andMe Research Team

Nature genetics · 2019 · PMID 30804565

Questions about rs12534945

What is rs12534945?

rs12534945 is a single position in the genome, in or near the PRKRIP1 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12534945 linked to?

On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.

Does having rs12534945 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12534945 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insomnia (rs12534945). MyGeneLog™. https://www.mygenelog.com/variants/rs12534945

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