Gene Knowledge Graph
UTC
Sensitive

Skin cancer

ADGRV1 · rs12523056

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs12523056 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin… Condition rs12523056 rs12523056 ADGRV1

What the study found

Who was studied 83,801 European ancestry cases, 347,397 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0378 higher (95% confidence interval 0.026-0.049); p = 3 × 10−12.

How common The T allele had a frequency of about 61% in the people studied.

Where it sits Chromosome 5, band 5q14.3 — in an intron of ADGRV1.

What each result means

C/C No copy of the version the research linked to Skin cancer. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Skin cancer. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Skin cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs12523056

What is rs12523056?

rs12523056 is a single position in the genome, in or near the ADGRV1 gene. Published research associates it with skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12523056 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs12523056 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12523056 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Skin cancer (rs12523056). MyGeneLog™. https://www.mygenelog.com/variants/rs12523056

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