Standard

Psoriasis

near ARL2BPP4 · rs12519814

Where this position leads

Condition: Psoriasis

rs12519814 Condition: Psoriasis Psoriasis Condition rs12519814 rs12519814 near ARL2BPP4

What the study found

Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.069 lower (95% confidence interval 0.063-0.075); p = 2 × 10−9.

Where it sits Chromosome 5, band 5q23.3 — between genes, 204.7 kb from ARL2BPP4.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source

Questions about rs12519814

What is rs12519814?

rs12519814 is a single position in the genome, in or near the near ARL2BPP4 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12519814 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs12519814 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12519814 come from?

GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs12519814). MyGeneLog™. https://www.mygenelog.com/variants/rs12519814

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