C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pediatric autoimmune diseases compared to the general population. (GWAS Catalog, Nat Med 2015, PMID:26301688)
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pediatric autoimmune diseases. (GWAS Catalog, Nat Med 2015, PMID:26301688)
G/GPublished research associates this genotype with typical/baseline likelihood of Pediatric autoimmune diseases — no copies of the reported risk allele. (GWAS Catalog, Nat Med 2015, PMID:26301688)
Source: GWAS Catalog, Nat Med 2015, PMID:26301688
Questions about rs1250563
What is rs1250563?
rs1250563 is a single position in the genome, in or near the ZMIZ1 gene. Published research associates it with pediatric autoimmune diseases. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1250563 linked to?
On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1250563 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1250563 come from?
GWAS Catalog, Nat Med 2015, PMID:26301688. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.