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Its strongest genetic-study result is p = 10−22, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 688 Japanese ancestry cases, 205,199 Japanese ancestry controls, 27,572 European ancestry cases, 1,436,801 European ancestry controls, 819 African ancestry cases, 155,904 African ancestry controls, 295 American ancestry ancestry cases, 45,659 American ancestry ancestry controls.
The effect
Each copy of the C allele carried 1.11 times the odds of Multiple sclerosis (95% confidence interval 1.09-1.13); p = 6 × 10−23.
Where it sits Chromosome 10, band 10q22.3 — in an intron of ZMIZ1.
What each result means
C/CTwo copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42706308 · open access
Questions about rs1250537
What is rs1250537?
rs1250537 is a single position in the genome, in or near the ZMIZ1 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1250537 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1250537 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1250537 come from?
GWAS Catalog, Nature genetics 2026, PMID:42706308. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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