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Pulmonary function

HHIP · rs12504628

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 20,288 European ancestry individuals; replicated in up to 54,276 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.077 s.d. lower (95% confidence interval 0.055-0.099); p = 6 × 10⁻¹³.

How common The T allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 4, band 4q31.21 — in an intron of LOC105377462.

What each result means

C/C No copy of the version the research linked to Pulmonary function. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Pulmonary function. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Pulmonary function. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies five loci associated with lung function

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W

and 83 more — show all

Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo N, Spector TD, Polasek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K, Cooper MN, James AL, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S, McKeever TM, Pavord ID, MacLeod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C, Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP, Tobin MD

Wellcome Trust Case Control Consortium · NSHD Respiratory Study Team

Nature genetics · 2010 · PMID 20010834

What people read about alongside this

Allergies1 Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12504628

What is rs12504628?

rs12504628 is a single position in the genome, in or near the HHIP gene. Published research associates it with pulmonary function. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12504628 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs12504628?

Subjects that appear in the title or abstract of the same papers as this rsID include allergies (1 papers), blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12504628 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12504628 come from?

GWAS Catalog, Nat Genet 2009, PMID:20010834. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary function (rs12504628). MyGeneLog™. https://www.mygenelog.com/variants/rs12504628

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