0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied at least 5,877 East Asian ancestry cases, at least 188,588 East Asian ancestry controls, at least 14,355 European ancestry cases, at least 505,956 European ancestry controls, at least 1,393 admixed American ancestry cases, at least 2,327 admixed American ancestry controls (MTAG boosted by autoimmune diseases samples).
The effect
Each copy of the G allele shifted the measure 0.054 lower (95% confidence interval 0.037-0.071); p = 8 × 10−10.
Where it sits Chromosome 3, band 3q13.33 — in an intron of IQCB1.
What each result means
A/ANo copy of the version the research linked to Systemic lupus erythematosus (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Systemic lupus erythematosus (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Systemic lupus erythematosus (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 36750564 · open access
Questions about rs12490565
What is rs12490565?
rs12490565 is a single position in the genome, in or near the IQCB1 gene. Published research associates it with systemic lupus erythematosus (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12490565 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs12490565 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12490565 come from?
GWAS Catalog, Nature communications 2023, PMID:36750564. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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